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產(chǎn)品名稱: RAD17 antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
RAD17 antibody迅速增長(zhǎng)的產(chǎn)品線包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。RAD17 antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
RAD17 antibody
的詳細(xì)介紹
RAD17 antibodyProduct Profile
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Product Name
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Rabbit anti-RAD17 polyclonal antibody - C-terminal region
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Antibody Type
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Primary Antibodies
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Immunogen
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The immunogen for anti-RAD17 antibody: synthetic peptide directed towards the C terminal of human RAD17
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RAD17 antibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Species Reactivity
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BovineDogHumanMousePigRat
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Concentration
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1mg/ml
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Purification
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Protein A
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RAD17 antibodyTarget Information
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Gene Symbol
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RAD17
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Gene Synonyms
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CCYC
HRAD17
R24L
RAD17Sp
Rad24
RAD24
RAD17SP
More
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Gene Full Name
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RAD17 homolog (S. pombe)
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Gene Summary
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RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.
More
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Alternative Names
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CCYC
HRAD17
R24L
RAD17Sp
Rad24
RAD24
RAD17SP
More
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Molecular Weight(MW)
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66kDa
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Sequence
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584 amino acids
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RAD17 antibodyDatabase Links
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Entrez Gene
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5884
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SwissProt ID
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O75943-4
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Protein Accession
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NP_579919
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RAD17 antibodyApplication
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Western blot
Positive Control: Lane1: 25ug Hela lysate, Lane2: 25ug HEK293T lysate, Lane3: 25ug Xenopus laevis egg extract, Lane4: 25ug mouse embryonic stem cells lysate
Primary Antibody Dilution : 1:500
Secondary Antibody : Anti-rabbit-HRP
Secondry Antibody Dilution : 1:3000
Submitted by: Domenico Maiorano, Institute of Human Genetics, CNRS
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Western blot
1.25ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
Additional Information
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Form
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Liquid
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Storage Instructions
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Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
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Storage Buffer
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phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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