ATF2 (phospho Ser62 / 44) Antibody
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產(chǎn)品名稱: ATF2 (phospho Ser62 / 44) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關文檔
簡單介紹
ATF2 (phospho Ser62 / 44) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。ATF2 (phospho Ser62 / 44) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
ATF2 (phospho Ser62 / 44) Antibody
的詳細介紹
ATF2 (phospho Ser62 / 44) AntibodyProduct Profile
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Product Name
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ATF2 (phospho Ser62 / 44) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.1) Sevilla A, et al. (2004) J Biol Chem. 279 (26): 27458-27465. Sakurai A, et al. (1991) Biochem Biophys Res Commun. 181 (2): 629-635. Abdel-Hafiz H A, et al. (1992) Mol Endocrinol. 6: 2079-2089. Gupta S, et al. (1995) Science. 267: 389-393. Van Dam H, et al. (1995) EMBO J. 14 (8): 1798-1811.
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Immunogen
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ATF2 (Phospho-Ser62 or 44) antibody was raised against a peptide sequence around phosphorylation site of serine 62 or 44 (N-D-S (p) -V-I) derived from Human ATF2.
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ATF2 (phospho Ser62 / 44) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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ATF2 (phospho Ser62 / 44) AntibodyTarget Information
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Gene Symbol
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ATF2
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Alternative Names
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HB16
CREB2
TREB7
CREB-2
CRE-BP1
MADH3
CREBP1
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Molecular Weight(MW)
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65 - 75 kDa
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Tissue Specificity
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This antibody detects endogenous level of ATF-2 only when phosphorylated at serine 62 or 44.
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ATF2 (phospho Ser62 / 44) AntibodyDatabase Links
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Entrez Gene
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1386
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Protein Accession
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NP_001871.2
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ATF2 (phospho Ser62 / 44) AntibodyApplication
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Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATF2 (Phospho-Ser62 or 44).
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Application
Western blot analysis of lysed extracts from MDA231 cells untreated or treated with UV using ATF2 (Phospho-Ser62 or 44).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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