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產品名稱: Mouse Rps6kb1 Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
Mouse Rps6kb1 Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Mouse Rps6kb1 Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
Mouse Rps6kb1 Antibody
的詳細介紹
Mouse Rps6kb1 AntibodyProduct Profile
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Product Name
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Mouse Rps6kb1 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Rps6kb1 acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-136' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-136'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates POLDIP3 (By similarity).1) Lai, K.P., et al. EMBO J. 29(17):2994-3006(2010)
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Immunogen
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This Mouse Rps6kb1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-509 amino acids from the C-terminal region of mouse Rps6kb1.
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Mouse Rps6kb1 AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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Ig
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Host Species
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Rabbit
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Tested Applications
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WB
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For WB starting dilution is: 1:1000:
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Species Reactivity
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HumanMouse
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Mouse Rps6kb1 AntibodyTarget Information
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Gene Symbol
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Rps6kb1
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Alternative Names
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Ribosomal protein S6 kinase beta-1
S6K-beta-1
S6K1
70 kDa ribosomal protein S6 kinase 1
P70S6K1
p70-S6K 1
Ribosomal protein S6 kinase I
S6K
p70 ribosomal S6 kinase alpha
p70 S6 kinase alpha
p70 S6K-alpha
p70 S6KA
Rps6kb1
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Molecular Weight(MW)
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59 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Bovine
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Mouse Rps6kb1 AntibodyDatabase Links
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Entrez Gene
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72508
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Protein Accession
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Q8BSK8
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Mouse Rps6kb1 AntibodyApplication
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Application
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
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Application
Western blot analysis in mouse heart tissue lysates (35ug/lane).
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Application Notes
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For WB starting dilution is: 1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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Supplied in PBS with 0.09% (W/V) sodium azide.
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