NFkB p105 / p50 (phospho Ser927) Antibody
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產(chǎn)品名稱(chēng): NFkB p105 / p50 (phospho Ser927) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
NFkB p105 / p50 (phospho Ser927) Antibody迅速增長(zhǎng)的產(chǎn)品線(xiàn)包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。NFkB p105 / p50 (phospho Ser927) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
NFkB p105 / p50 (phospho Ser927) Antibody
的詳細(xì)介紹
NFkB p105 / p50 (phospho Ser927) AntibodyProduct Profile
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Product Name
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NFkB p105 / p50 (phospho Ser927) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.1) Hou S, et al. (2003) J Biol Chem. 278 (46): 45994-45998. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.
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Immunogen
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NFkB-p105/p50 (Phospho-Ser927) antibody was raised against a peptide sequence around phosphorylation site of serine 927 (C-D-S (p) -G-V) derived from Human NFκB-p105.
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NFkB p105 / p50 (phospho Ser927) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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NFkB p105 / p50 (phospho Ser927) AntibodyTarget Information
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Gene Symbol
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NFKB1
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Alternative Names
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p50
KBF1
p105
EBP-1
NF-kB1
NFKB-p50
NFkappaB
NF-kappaB
NFKB-p105
NF-kappa-B
SHC
SHCA
DNA-binding factor KBF1
NF-kappa-B1 p84/NF-kappa-B1 p98
NFKB1
NFkB-p50
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Molecular Weight(MW)
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50, 120 kDa
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Tissue Specificity
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This antibody detects endogenous level of NFκB-p105/p50 only when phosphorylated at serine 927.
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NFkB p105 / p50 (phospho Ser927) AntibodyDatabase Links
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Entrez Gene
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4790
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Protein Accession
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NP_001158884.1
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NFkB p105 / p50 (phospho Ser927) AntibodyApplication
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p105/p50 (Phospho-Ser927). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using NFκB-p105/p50 (Phospho-Ser927).
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Application
Western blot analysis of lysed extracts from HL60 cells untreated or treated with TNF-α using NFκB-p105/p50 (Phospho-Ser927).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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